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Differently from what observed in the normal intestine, the expression of most NRs is downregulated in patients with familial adenomatous polyposis (FAP) and in ApcMin/+ mice (an animal model of CRC), while only few are upregulated[20]. For instance, loss of ERβ and VDR in mice results in colon cell hyper-proliferation[21,22]. On the other hand, the expression of other NRs, such as EAR-2, is induced in CRC models and is downregulated in HT29 colon cancer cells upon restoration of the activity of wild type APC[19]. In both cases, variations in NR expression/activity seem to be directly related to the WNT signaling pathway and indeed, many NRs cross-talk with the WNT signaling pathway[18].

The Internet is a global system of interconnected computer networks that use the Internet protocol suite (TCP/IP) to link several billion devices worldwide. It is a network of networks that consists of millions of private, public, academic, business, and government networks of local to global scope, linked by a broad array of electronic, wireless, and optical networking technologies. The Internet carries an extensive range of information resources and services, such as the inter-linked hypertext documents and applications of the World Wide Web (WWW), electronic mail, telephony, and peer-to-peer networks for file sharing.

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HTTP - The Hypertext Transfer Protocol (HTTP) is an application protocol for distributed, collaborative, hypermedia information systems. HTTP is the foundation of data communication for the World Wide Web. 2ff7e9595c